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Cruise Advisory
Please be aware of any coronavirus (COVID-19) cruise advisories and review updates from the World Health Organization (WHO).
  • Destinations
    South America
  • Departure Ports
    Any Port
  • Departure Date Range
    Any Date
  • Adults (25+)
    2

307 Cruises

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  • 7-Night South America Cruise

    7-Night South America Cruise
    MSC Cruises
    MSC Fantasia
    Depart: Sun, Dec 13, 2020
    Returns: Sun, Dec 20, 2020
    Depart – Santos, Brazil
    • At Sea
    • Punta del Este, Uruguay
    • Buenos Aires, Argentina
    • Buenos Aires, Argentina
    • Montevideo, Uruguay
    • At Sea
    Returns – Santos, Brazil
    Santos, Brazil - At Sea - Punta del Este, Uruguay - Buenos Aires, Argentina - Buenos Aires, Argentina - Montevideo, Uruguay - At Sea - Santos, Brazil
    from
    $629* USD
    *restrictions apply
    Gov't fees & taxes from: $98/pp.


  • 3-Night South America Cruise

    3-Night South America Cruise
    MSC Cruises
    MSC Preziosa
    Depart: Sun, Dec 13, 2020
    Returns: Wed, Dec 16, 2020
    Depart – Rio de Janeiro, Brazil
    • Buzios, Brazil
    • At Sea
    Returns – Salvador, Brazil
    Rio de Janeiro, Brazil - Buzios, Brazil - At Sea - Salvador, Brazil
    from
    $269* USD
    *restrictions apply
    Gov't fees & taxes from: $42/pp.
  • 7-Night South America Cruise

    7-Night South America Cruise
    MSC Cruises
    MSC Fantasia
    Depart: Sun, Jan 24, 2021
    Returns: Sun, Jan 31, 2021
    Depart – Santos, Brazil
    • At Sea
    • Montevideo, Uruguay
    • Buenos Aires, Argentina
    • Buenos Aires, Argentina
    • Punta del Este, Uruguay
    • At Sea
    Returns – Santos, Brazil
    Santos, Brazil - At Sea - Montevideo, Uruguay - Buenos Aires, Argentina - Buenos Aires, Argentina - Punta del Este, Uruguay - At Sea - Santos, Brazil
    Expedia® Extras* (Extras vary and apply to select staterooms and prices)
    • Reduced Deposit - Only $49 per person
    from
    $729* USD
    *restrictions apply
    Gov't fees & taxes from: $98/pp.
  • 7-Night South America Cruise

    7-Night South America Cruise
    MSC Cruises
    MSC Grandiosa
    Depart: Sat, Feb 20, 2021
    Returns: Sat, Feb 27, 2021
    Depart – Santos, Brazil
    • Buzios, Brazil
    • At Sea
    • Salvador, Brazil
    • Ilheus, Brazil
    • At Sea
    • Ilha Grande, Brazil
    Returns – Santos, Brazil
    Santos, Brazil - Buzios, Brazil - At Sea - Salvador, Brazil - Ilheus, Brazil - At Sea - Ilha Grande, Brazil - Santos, Brazil
    Expedia® Extras* (Extras vary and apply to select staterooms and prices)
    • Reduced Deposit - Only $49 per person
    from
    $759* USD
    *restrictions apply
    Gov't fees & taxes from: $98/pp.
  • 3-Night South America Cruise

    3-Night South America Cruise
    MSC Cruises
    MSC Preziosa
    Depart: Mon, Mar 15, 2021
    Returns: Thu, Mar 18, 2021
    Depart – Santos, Brazil
    • Porto Belo, Brazil
    • Balneario Camboriu, Brazil
    Returns – Santos, Brazil
    Santos, Brazil - Porto Belo, Brazil - Balneario Camboriu, Brazil - Santos, Brazil
    Expedia® Extras* (Extras vary and apply to select staterooms and prices)
    • Reduced Deposit - Only $49 per person
    from
    $289* USD
    *restrictions apply
    Gov't fees & taxes from: $59/pp.
  • 14-Night South America Cruise

    BEST
    VALUE*
    14-Night South America Cruise
    Celebrity Cruises
    Celebrity Silhouette
    Depart: Sun, Dec 6, 2020
    Returns: Sun, Dec 20, 2020
    Depart – Buenos Aires, Argentina
    • Buenos Aires, Argentina
    • Montevideo, Uruguay
    • Punta del Este, Uruguay
    • At Sea
    • Puerto Madryn, Argentina
    • At Sea
    • Cape Horn, Chile
    • Ushuaia, Argentina
    • Punta Arenas, Chile
    • Strait of Magellan, Chile
    • Chilean Fjords, Chile
    • Puerto Montt, Chile
    • At Sea
    Returns – San Antonio, Chile
    Buenos Aires, Argentina - Buenos Aires, Argentina - Montevideo, Uruguay - Punta del Este, Uruguay - At Sea - Puerto Madryn, Argentina - At Sea - Cape Horn, Chile - Ushuaia, Argentina - Punta Arenas, Chile - Strait of Magellan, Chile - Chilean Fjords, Chile - Puerto Montt, Chile - At Sea - San Antonio, Chile
    Expedia® Extras* (Extras vary and apply to select staterooms and prices)
    • Sail Plus! Beverage Package & WiFi
    • Sail Plus! Beverage Package & Tips
    • Sail Plus! Beverage Package & $300 Credit
    • show more 
    from
    $1,499* USD
    *restrictions apply
    Gov't fees & taxes from: $378/pp.
  • 2-Night South America Cruise

    2-Night South America Cruise
    MSC Cruises
    MSC Preziosa
    Depart: Wed, Jan 27, 2021
    Returns: Fri, Jan 29, 2021
    Depart – Salvador, Brazil
    Returns – Rio de Janeiro, Brazil
    Salvador, Brazil - At Sea - Rio de Janeiro, Brazil
    Expedia® Extras* (Extras vary and apply to select staterooms and prices)
    • Reduced Deposit - Only $49 per person
    from
    $209* USD
    *restrictions apply
    Gov't fees & taxes from: $81/pp.
  • 14-Night South America Cruise

    BEST
    VALUE*
    14-Night South America Cruise
    Celebrity Cruises
    Celebrity Silhouette
    Depart: Sun, Feb 28, 2021
    Returns: Sun, Mar 14, 2021
    Depart – San Antonio, Chile
    • La Serena, Chile
    • At Sea
    • At Sea
    • Pisco, Peru
    • Lima, Peru
    • Lima, Peru
    • Lima, Peru
    • At Sea
    • Arica, Chile
    • At Sea
    • At Sea
    • At Sea
    • At Sea
    Returns – San Antonio, Chile
    San Antonio, Chile - La Serena, Chile - At Sea - At Sea - Pisco, Peru - Lima, Peru - Lima, Peru - Lima, Peru - At Sea - Arica, Chile - At Sea - At Sea - At Sea - At Sea - San Antonio, Chile
    Expedia® Extras* (Extras vary and apply to select staterooms and prices)
    • Sail Plus! Beverage Package & WiFi
    • Sail Plus! Beverage Package & Tips
    • Sail Plus! Beverage Package & $300 Credit
    • show more 
    from
    $1,299* USD
    *restrictions apply
    Gov't fees & taxes from: $288/pp.
  • 14-Night South America Cruise

    BEST
    VALUE*
    14-Night South America Cruise
    Celebrity Cruises
    Celebrity Silhouette
    Depart: Sun, Dec 20, 2020
    Returns: Sun, Jan 3, 2021
    Depart – San Antonio, Chile
    • At Sea
    • Puerto Montt, Chile
    • Chilean Fjords, Chile
    • Strait of Magellan, Chile
    • Punta Arenas, Chile
    • Ushuaia, Argentina
    • Cape Horn, Chile
    • At Sea
    • Puerto Madryn, Argentina
    • At Sea
    • Punta del Este, Uruguay
    • Montevideo, Uruguay
    • Buenos Aires, Argentina
    Returns – Buenos Aires, Argentina
    San Antonio, Chile - At Sea - Puerto Montt, Chile - Chilean Fjords, Chile - Strait of Magellan, Chile - Punta Arenas, Chile - Ushuaia, Argentina - Cape Horn, Chile - At Sea - Puerto Madryn, Argentina - At Sea - Punta del Este, Uruguay - Montevideo, Uruguay - Buenos Aires, Argentina - Buenos Aires, Argentina
    Expedia® Extras* (Extras vary and apply to select staterooms and prices)
    • Sail Plus! Beverage Package & WiFi
    • Sail Plus! Beverage Package & Tips
    • Sail Plus! Beverage Package & $300 Credit
    • show more 
    from
    $1,599* USD
    *restrictions apply
    Gov't fees & taxes from: $315/pp.
  • 14-Night South America Cruise

    up to
    $1000
    CREDIT*
    14-Night South America Cruise
    Norwegian Cruise Line
    Norwegian Star
    Depart: Sat, Dec 19, 2020
    Returns: Sat, Jan 2, 2021
    Depart – Buenos Aires, Argentina
    • Montevideo, Uruguay
    • At Sea
    • Puerto Madryn, Argentina
    • At Sea
    • Port Stanley, Falkland Islands (Malvinas)
    • Cape Horn, Chile
    • Ushuaia, Argentina
    • Punta Arenas, Chile
    • At Sea
    • At Sea
    • Puerto Chacabuco, Chile
    • Puerto Montt, Chile
    • At Sea
    Returns – San Antonio, Chile
    Buenos Aires, Argentina - Montevideo, Uruguay - At Sea - Puerto Madryn, Argentina - At Sea - Port Stanley, Falkland Islands (Malvinas) - Cape Horn, Chile - Ushuaia, Argentina - Punta Arenas, Chile - At Sea - At Sea - Puerto Chacabuco, Chile - Puerto Montt, Chile - At Sea - San Antonio, Chile
    Expedia® Extras* (Extras vary and apply to select staterooms and prices)
    • Dash Sale! Up to $1000 Onboard Cash Credit - Ends 4/10
    • FREE Drinks, Excursion Credit & WiFi
    • FREE Dining, Excursion Credit & WiFi
    • show more 
    from
    $1,238* USD
    *restrictions apply
    Gov't fees & taxes from: $384/pp.

Terms & Conditions

*Expedia Extras offers are per stateroom (unless otherwise stated) on select sailings, based on double occupancy, apply to new bookings only, are not combinable with any other offer, are capacity controlled and may be withdrawn without notice. Certain restrictions may apply. For full terms and conditions, click the specific Expedia Extra offer or contact your Expedia CruiseShipCenters Vacation Consultant.

Prices are per person (based on 2 passengers in the same stateroom), cruise only in USD dollars. Airfare, transfers, taxes, fees and port expenses are additional (unless otherwise stated). Prices vary by ship, stateroom type and sailing date. Prices and offers are subject to availability and change without notice, and are capacity controlled. Fuel supplement may apply. Expedia CruiseShipCenters is not responsible for errors that may occur due to the transfer of information from selected third parties, technical error, or human error.

Our default sort order is based on a number of relevant factors such as cruise line rating, ship rating, price per day, origin rating, destination rating, length of cruise, and booking window.

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