1-800-707-7327

Call Us Today!

  • Destinations
    South America
  • Departure Ports
    Any Port
  • Departure Date Range
    Any Date
  • Adults (25+)
    2

388 Cruises

Show Search Filters
Loading
from
to

Questions? 1-800-707-7327

  • 3-Night South America Cruise

    3-Night South America Cruise
    MSC Cruises
    MSC Fantasia
    Depart: Wed, Feb 19, 2020
    Returns: Sat, Feb 22, 2020
    Depart – Rio de Janeiro, Brazil
    • Ilha Grande, Brazil
    • IlhaBela, Brazil
    Returns – Rio de Janeiro, Brazil
    Rio de Janeiro, Brazil - Ilha Grande, Brazil - IlhaBela, Brazil - Rio de Janeiro, Brazil
    from
    $379* USD
    *restrictions apply
    Gov't fees & taxes from: $69/pp.


  • 4-Night South America Cruise

    4-Night South America Cruise
    MSC Cruises
    MSC Fantasia
    Depart: Mon, Dec 2, 2019
    Returns: Fri, Dec 6, 2019
    Depart – Santos, Brazil
    • Rio de Janeiro, Brazil
    • At Sea
    • Ilha Grande, Brazil
    Returns – Rio de Janeiro, Brazil
    Santos, Brazil - Rio de Janeiro, Brazil - At Sea - Ilha Grande, Brazil - Rio de Janeiro, Brazil
    from
    $409* USD
    *restrictions apply
    Gov't fees & taxes from: $56/pp.
  • 7-Night South America Cruise

    7-Night South America Cruise
    MSC Cruises
    MSC Sinfonia
    Depart: Mon, Jan 6, 2020
    Returns: Mon, Jan 13, 2020
    Depart – Montevideo, Uruguay
    • Buenos Aires, Argentina
    • At Sea
    • At Sea
    • Santos, Brazil
    • Itajai, Brazil
    • At Sea
    Returns – Montevideo, Uruguay
    Montevideo, Uruguay - Buenos Aires, Argentina - At Sea - At Sea - Santos, Brazil - Itajai, Brazil - At Sea - Montevideo, Uruguay
    from
    $679* USD
    *restrictions apply
    Gov't fees & taxes from: $174/pp.
  • 7-Night South America Cruise

    7-Night South America Cruise
    MSC Cruises
    MSC Sinfonia
    Depart: Tue, Mar 3, 2020
    Returns: Tue, Mar 10, 2020
    Depart – Buenos Aires, Argentina
    • At Sea
    • At Sea
    • Santos, Brazil
    • Itajai, Brazil
    • At Sea
    • Montevideo, Uruguay
    Returns – Buenos Aires, Argentina
    Buenos Aires, Argentina - At Sea - At Sea - Santos, Brazil - Itajai, Brazil - At Sea - Montevideo, Uruguay - Buenos Aires, Argentina
    from
    $589* USD
    *restrictions apply
    Gov't fees & taxes from: $190/pp.
  • 8-Night South America Cruise

    8-Night South America Cruise
    Costa Cruises
    Costa Fascinosa
    Depart: Sat, Jan 25, 2020
    Returns: Sun, Feb 2, 2020
    Depart – Santos, Brazil
    • At Sea
    • At Sea
    • Buenos Aires, Argentina
    • Buenos Aires, Argentina
    • Montevideo, Uruguay
    • At Sea
    • At Sea
    Returns – Santos, Brazil
    Santos, Brazil - At Sea - At Sea - Buenos Aires, Argentina - Buenos Aires, Argentina - Montevideo, Uruguay - At Sea - At Sea - Santos, Brazil
    from
    $1,029* USD
    *restrictions apply
    Gov't fees & taxes from: $223/pp.
  • 14-Night South America Cruise

    BEST
    VALUE*
    14-Night South America Cruise
    Holland America Line
    ms Westerdam
    Depart: Fri, Oct 30, 2020
    Returns: Fri, Nov 13, 2020
    Depart – San Antonio, Chile
    • At Sea
    • Puerto Montt, Chile
    • Puerto Chacabuco, Chile
    • Chilean Fjords, Chile
    • Amalia Glacier, Chile
    • Strait of Magellan, Chile
    • Punta Arenas, Chile
    • Beagle Channel (Argentina/Chile)
    • Beagle Channel (Argentina/Chile)
    • Glacier Alley, Chile
    • Ushuaia, Argentina
    • Cape Horn, Chile
    • Port Stanley, Falkland Islands (Malvinas)
    • At Sea
    • At Sea
    • Montevideo, Uruguay
    • Buenos Aires, Argentina
    Returns – Buenos Aires, Argentina
    San Antonio, Chile - At Sea - Puerto Montt, Chile - Puerto Chacabuco, Chile - Chilean Fjords, Chile - Amalia Glacier, Chile - Strait of Magellan, Chile - Punta Arenas, Chile - Beagle Channel (Argentina/Chile) - Beagle Channel (Argentina/Chile) - Glacier Alley, Chile - Ushuaia, Argentina - Cape Horn, Chile - Port Stanley, Falkland Islands (Malvinas) - At Sea - At Sea - Montevideo, Uruguay - Buenos Aires, Argentina - Buenos Aires, Argentina
    Expedia® Extras* (Extras vary and apply to select staterooms and prices)
    • Early Booking Bonus! FREE Beverages, Specialty Dining, and more (select rates)
    • Limited Availability! Reduced Rates
    from
    $1,499* USD
    *restrictions apply
  • 8-Night South America Cruise

    8-Night South America Cruise
    MSC Cruises
    MSC Fantasia
    Depart: Sat, Jan 18, 2020
    Returns: Sun, Jan 26, 2020
    Depart – Rio de Janeiro, Brazil
    • At Sea
    • At Sea
    • Buenos Aires, Argentina
    • Buenos Aires, Argentina
    • Punta del Este, Uruguay
    • At Sea
    • IlhaBela, Brazil
    Returns – Rio de Janeiro, Brazil
    Rio de Janeiro, Brazil - At Sea - At Sea - Buenos Aires, Argentina - Buenos Aires, Argentina - Punta del Este, Uruguay - At Sea - IlhaBela, Brazil - Rio de Janeiro, Brazil
    from
    $849* USD
    *restrictions apply
    Gov't fees & taxes from: $102/pp.
  • 8-Night South America Cruise

    up to
    $500
    CREDIT*
    8-Night South America Cruise
    Azamara Club Cruises
    Azamara Pursuit
    Depart: Sat, Nov 30, 2019
    Returns: Sun, Dec 8, 2019
    Depart – Rio de Janeiro, Brazil
    • Rio de Janeiro, Brazil
    • IlhaBela, Brazil
    • Santos, Brazil
    • At Sea
    • At Sea
    • Montevideo, Uruguay
    • Punta del Este, Uruguay
    Returns – Buenos Aires, Argentina
    Rio de Janeiro, Brazil - Rio de Janeiro, Brazil - IlhaBela, Brazil - Santos, Brazil - At Sea - At Sea - Montevideo, Uruguay - Punta del Este, Uruguay - Buenos Aires, Argentina
    Expedia® Extras* (Extras vary and apply to select staterooms and prices)
    • Share & Save Sale offers 50% Off 2nd Guest, $500 Onboard Credit, and Free Internet
    from
    $1,199* USD
    *restrictions apply
    Gov't fees & taxes from: $312/pp.
  • 4-Night South America Cruise

    4-Night South America Cruise
    MSC Cruises
    MSC Seaview
    Depart: Mon, Mar 9, 2020
    Returns: Fri, Mar 13, 2020
    Depart – Santos, Brazil
    • Balneario Camboriu, Brazil
    • Porto Belo, Brazil
    • At Sea
    Returns – Santos, Brazil
    Santos, Brazil - Balneario Camboriu, Brazil - Porto Belo, Brazil - At Sea - Santos, Brazil
    from
    $509* USD
    *restrictions apply
    Gov't fees & taxes from: $55/pp.
  • 8-Night South America Cruise

    8-Night South America Cruise
    Costa Cruises
    Costa Pacifica
    Depart: Wed, Dec 4, 2019
    Returns: Thu, Dec 12, 2019
    Depart – Buenos Aires, Argentina
    • At Sea
    • At Sea
    • Rio de Janeiro, Brazil
    • Ilha Grande, Brazil
    • IlhaBela, Brazil
    • At Sea
    • Montevideo, Uruguay
    Returns – Buenos Aires, Argentina
    Buenos Aires, Argentina - At Sea - At Sea - Rio de Janeiro, Brazil - Ilha Grande, Brazil - IlhaBela, Brazil - At Sea - Montevideo, Uruguay - Buenos Aires, Argentina
    from
    $809* USD
    *restrictions apply
    Gov't fees & taxes from: $300/pp.

Terms & Conditions

*Expedia Extras offers are per stateroom (unless otherwise stated) on select sailings, based on double occupancy, apply to new bookings only, are not combinable with any other offer, are capacity controlled and may be withdrawn without notice. Certain restrictions may apply. For full terms and conditions, click the specific Expedia Extra offer or contact your Expedia CruiseShipCenters Vacation Consultant.

For Bookings Made in Quebec: Travel Agents’ Customers Compensation Fund FICAV (0.10% or 1$ per 1000$ of tourism products).

Prices are per person (based on 2 passengers in the same stateroom), cruise only in USD dollars. Airfare, transfers, taxes, fees and port expenses are additional (unless otherwise stated). Prices vary by ship, stateroom type and sailing date. Prices and offers are subject to availability and change without notice, and are capacity controlled. Fuel supplement may apply. Expedia CruiseShipCenters is not responsible for errors that may occur due to the transfer of information from selected third parties, technical error, or human error.

Our default sort order is based on a number of relevant factors such as cruise line rating, ship rating, price per day, origin rating, destination rating, length of cruise, and booking window.

Our Promise


At Expedia CruiseShipCenters, we are navigators of spectacular vacation experiences. As part of the number one brand in travel, this is our promise to you:


Learn More 
  • Advice you can trust.

  • The best choice in prices.

  • Expedia Extras.

  • More than cruises.

  • Always there.


Find an Expedia CruiseShipCenters Near You

Enter your Zip code