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    Panama Canal
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    Any Port
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  • Adults (25+)
    2

290 Cruises

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  • 10-Night Panama Canal Cruise

    10-Night Panama Canal Cruise
    Carnival Cruise Lines
    Carnival Fantasy
    Depart: Mon, Sep 14, 2020
    Returns: Thu, Sep 24, 2020
    Depart – Mobile, Alabama
    • At Sea
    • At Sea
    • At Sea
    • Panama Canal
    • Puerto Limon, Costa Rica
    • At Sea
    • Roatan, Honduras
    • Cozumel, Mexico
    • At Sea
    Returns – Mobile, Alabama
    Mobile, Alabama - At Sea - At Sea - At Sea - Panama Canal - Puerto Limon, Costa Rica - At Sea - Roatan, Honduras - Cozumel, Mexico - At Sea - Mobile, Alabama
    Expedia® Extras* (Extras vary and apply to select staterooms and prices)
    • Early Saver + Reduced Deposit + $1 Upgrade - Ends 1/21
    • Great Rates
    from
    $569* USD
    *restrictions apply
    Gov't fees & taxes from: $321/pp.


  • 9-Night Panama Canal Cruise

    9-Night Panama Canal Cruise
    Carnival Cruise Lines
    Carnival Radiance
    Depart: Fri, Nov 26, 2021
    Returns: Sun, Dec 5, 2021
    Depart – Galveston, Texas
    • At Sea
    • Cozumel, Mexico
    • At Sea
    • Puerto Limon, Costa Rica
    • Panama Canal
    • At Sea
    • At Sea
    • At Sea
    Returns – Galveston, Texas
    Galveston, Texas - At Sea - Cozumel, Mexico - At Sea - Puerto Limon, Costa Rica - Panama Canal - At Sea - At Sea - At Sea - Galveston, Texas
    Expedia® Extras* (Extras vary and apply to select staterooms and prices)
    • Early Saver + Reduced Deposit + $1 Upgrade - Ends 1/21
    • Great Rates
    from
    $719* USD
    *restrictions apply
    Gov't fees & taxes from: $282/pp.
  • 8-Night Panama Canal Cruise

    8-Night Panama Canal Cruise
    Carnival Cruise Lines
    Carnival Legend
    Depart: Sat, Dec 12, 2020
    Returns: Sun, Dec 20, 2020
    Depart – Tampa, Florida
    • At Sea
    • At Sea
    • Puerto Limon, Costa Rica
    • Panama Canal
    • At Sea
    • Georgetown, Grand Cayman, Cayman Islands
    • At Sea
    Returns – Tampa, Florida
    Tampa, Florida - At Sea - At Sea - Puerto Limon, Costa Rica - Panama Canal - At Sea - Georgetown, Grand Cayman- At Sea - Tampa, Florida
    Expedia® Extras* (Extras vary and apply to select staterooms and prices)
    • Early Saver + Reduced Deposit + $1 Upgrade - Ends 1/21
    • Great Rates
    from
    $854* USD
    *restrictions apply
    Gov't fees & taxes from: $320/pp.
  • 8-Night Panama Canal Cruise

    8-Night Panama Canal Cruise
    Carnival Cruise Lines
    Carnival Legend
    Depart: Sat, Jan 25, 2020
    Returns: Sun, Feb 2, 2020
    Depart – Tampa, Florida
    • At Sea
    • At Sea
    • Puerto Limon, Costa Rica
    • Panama Canal
    • At Sea
    • Georgetown, Grand Cayman, Cayman Islands
    • At Sea
    Returns – Tampa, Florida
    Tampa, Florida - At Sea - At Sea - Puerto Limon, Costa Rica - Panama Canal - At Sea - Georgetown, Grand Cayman- At Sea - Tampa, Florida
    Expedia® Extras* (Extras vary and apply to select staterooms and prices)
    • FREE Cabin Upgrade! Ends 1/21
    from
    $1,009* USD
    *restrictions apply
    Gov't fees & taxes from: $316/pp.
  • 11-Night Panama Canal Cruise

    11-Night Panama Canal Cruise
    Holland America Line
    ms Zuiderdam
    Depart: Sat, Feb 15, 2020
    Returns: Wed, Feb 26, 2020
    Depart – Fort Lauderdale, Florida
    • Half Moon Cay, Bahamas
    • At Sea
    • Oranjestad, Aruba
    • Willemstad, Curacao, Netherlands Antilles
    • At Sea
    • Cartagena, Colombia
    • Panama Canal
    • Colon, Panama
    • Puerto Limon, Costa Rica
    • At Sea
    • At Sea
    Returns – Fort Lauderdale, Florida
    Fort Lauderdale, Florida - Half Moon Cay, Bahamas - At Sea - Oranjestad, Aruba - Willemstad, Curacao- At Sea - Cartagena, Colombia - Panama Canal - Colon, Panama - Puerto Limon, Costa Rica - At Sea - At Sea - Fort Lauderdale, Florida
    Expedia® Extras* (Extras vary and apply to select staterooms and prices)
    • FREE Beverage Package with select rates
    • $50 Onboard Cash Credit
    from
    $986* USD
    *restrictions apply
  • 14-Night Panama Canal Cruise

    14-Night Panama Canal Cruise
    Carnival Cruise Lines
    Carnival Glory
    Depart: Sun, Nov 29, 2020
    Returns: Sun, Dec 13, 2020
    Depart – New Orleans, Louisiana
    • At Sea
    • At Sea
    • Montego Bay, Jamaica
    • At Sea
    • Oranjestad, Aruba
    • Kralendijk, Bonaire, Netherlands Antilles
    • At Sea
    • Cartagena, Colombia
    • Colon, Panama
    • Puerto Limon, Costa Rica
    • At Sea
    • Cozumel, Mexico
    • At Sea
    Returns – New Orleans, Louisiana
    New Orleans, Louisiana - At Sea - At Sea - Montego Bay, Jamaica - At Sea - Oranjestad, Aruba - Kralendijk, Bonaire- At Sea - Cartagena, Colombia - Colon, Panama - Puerto Limon, Costa Rica - At Sea - Cozumel, Mexico - At Sea - New Orleans, Louisiana
    Expedia® Extras* (Extras vary and apply to select staterooms and prices)
    • Early Saver + Reduced Deposit + $1 Upgrade - Ends 1/21
    • Great Rates
    from
    $929* USD
    *restrictions apply
    Gov't fees & taxes from: $143/pp.
  • 10-Night Panama Canal Cruise

    10-Night Panama Canal Cruise
    Holland America Line
    ms Zuiderdam
    Depart: Sun, Oct 18, 2020
    Returns: Wed, Oct 28, 2020
    Depart – Fort Lauderdale, Florida
    • Half Moon Cay, Bahamas
    • At Sea
    • Oranjestad, Aruba
    • Willemstad, Curacao, Netherlands Antilles
    • At Sea
    • Panama Canal
    • Colon, Panama
    • Puerto Limon, Costa Rica
    • At Sea
    • At Sea
    Returns – Fort Lauderdale, Florida
    Fort Lauderdale, Florida - Half Moon Cay, Bahamas - At Sea - Oranjestad, Aruba - Willemstad, Curacao- At Sea - Panama Canal - Colon, Panama - Puerto Limon, Costa Rica - At Sea - At Sea - Fort Lauderdale, Florida
    Expedia® Extras* (Extras vary and apply to select staterooms and prices)
    • Suite Offer - FREE Premium Internet Package
    • View & Verandah Sale Suite Bonus - FREE Prepaid Gratuities
    • View & Verandah Sale - FREE Upgrades, Onboard Credit, Save on Shore Excursions, and more (select rates)!
    • show more 
    from
    $1,099* USD
    *restrictions apply
  • 10-Night Panama Canal Cruise

    BEST
    VALUE*
    10-Night Panama Canal Cruise
    Princess Cruises
    Emerald Princess
    Depart: Mon, Jan 4, 2021
    Returns: Thu, Jan 14, 2021
    Depart – Fort Lauderdale, Florida
    • At Sea
    • Montego Bay, Jamaica
    • At Sea
    • Cartagena, Colombia
    • Panama Canal
    • San Cristobal, Panama
    • Puerto Limon, Costa Rica
    • At Sea
    • Grand Cayman, Cayman Islands
    • At Sea
    Returns – Fort Lauderdale, Florida
    Fort Lauderdale, Florida - At Sea - Montego Bay, Jamaica - At Sea - Cartagena, Colombia - Panama Canal - San Cristobal, Panama - Puerto Limon, Costa Rica - At Sea - Grand Cayman, Cayman Islands - At Sea - Fort Lauderdale, Florida
    Expedia® Extras* (Extras vary and apply to select staterooms and prices)
    • Best.Sale.Ever - FREE Drinks, Gratuities, Wifi and more on select rates!
    • Non Refundable Deposit on select rates
    from
    $879* USD
    *restrictions apply
  • 10-Night Panama Canal Cruise

    BEST
    VALUE*
    10-Night Panama Canal Cruise
    Princess Cruises
    Crown Princess
    Depart: Mon, Feb 1, 2021
    Returns: Thu, Feb 11, 2021
    Depart – Fort Lauderdale, Florida
    • At Sea
    • Grand Turk Island, Turks and Caicos Islands
    • At Sea
    • Cartagena, Colombia
    • Panama Canal
    • San Cristobal, Panama
    • Puerto Limon, Costa Rica
    • At Sea
    • Falmouth, Jamaica
    • At Sea
    Returns – Fort Lauderdale, Florida
    Fort Lauderdale, Florida - At Sea - Grand Turk Island, Turks and Caicos Islands - At Sea - Cartagena, Colombia - Panama Canal - San Cristobal, Panama - Puerto Limon, Costa Rica - At Sea - Falmouth, Jamaica - At Sea - Fort Lauderdale, Florida
    Expedia® Extras* (Extras vary and apply to select staterooms and prices)
    • Best.Sale.Ever - FREE Drinks, Gratuities, Wifi and more on select rates!
    • Non Refundable Deposit on select rates
    from
    $929* USD
    *restrictions apply
  • 11-Night Panama Canal Cruise

    up to
    $50
    CREDIT*
    11-Night Panama Canal Cruise
    Norwegian Cruise Line
    Norwegian Pearl
    Depart: Thu, Apr 30, 2020
    Returns: Mon, May 11, 2020
    Depart – Miami, Florida
    • At Sea
    • At Sea
    • Cartagena, Colombia
    • Panama Canal
    • Colon, Panama
    • Puerto Limon, Costa Rica
    • At Sea
    • Roatan, Honduras
    • Harvest Caye, Belize
    • Costa Maya, Mexico
    • At Sea
    Returns – Miami, Florida
    Miami, Florida - At Sea - At Sea - Cartagena, Colombia - Panama Canal - Colon, Panama - Puerto Limon, Costa Rica - At Sea - Roatan, Honduras - Harvest Caye, Belize - Costa Maya, Mexico - At Sea - Miami, Florida
    Expedia® Extras* (Extras vary and apply to select staterooms and prices)
    • NCL 30% Off All Guests - Ends 1/20
    • FREE Dining, Excursion Credit & WiFi
    • FREE Drinks, Dining, Excursion Credit & WiFi
    • show more 
    from
    $678* USD
    *restrictions apply
    Gov't fees & taxes from: $453/pp.

Terms & Conditions

*Expedia Extras offers are per stateroom (unless otherwise stated) on select sailings, based on double occupancy, apply to new bookings only, are not combinable with any other offer, are capacity controlled and may be withdrawn without notice. Certain restrictions may apply. For full terms and conditions, click the specific Expedia Extra offer or contact your Expedia CruiseShipCenters Vacation Consultant.

For Bookings Made in Quebec: Travel Agents’ Customers Compensation Fund FICAV (0.10% or 1$ per 1000$ of tourism products).

Prices are per person (based on 2 passengers in the same stateroom), cruise only in USD dollars. Airfare, transfers, taxes, fees and port expenses are additional (unless otherwise stated). Prices vary by ship, stateroom type and sailing date. Prices and offers are subject to availability and change without notice, and are capacity controlled. Fuel supplement may apply. Expedia CruiseShipCenters is not responsible for errors that may occur due to the transfer of information from selected third parties, technical error, or human error.

Our default sort order is based on a number of relevant factors such as cruise line rating, ship rating, price per day, origin rating, destination rating, length of cruise, and booking window.

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