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    Panama Canal
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276 Cruises

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  • 11-Night Panama Canal Cruise

    BEST
    VALUE*
    11-Night Panama Canal Cruise
    Holland America Line
    ms Zuiderdam
    Depart: Wed, Nov 18, 2020
    Returns: Sun, Nov 29, 2020
    Depart – Fort Lauderdale, Florida
    • Half Moon Cay, Bahamas
    • At Sea
    • Oranjestad, Aruba
    • Willemstad, Curacao, Netherlands Antilles
    • At Sea
    • Cartagena, Colombia
    • Panama Canal
    • Gatun Lake, Panama
    • Panama Canal
    • Colon, Panama
    • Puerto Limon, Costa Rica
    • At Sea
    • At Sea
    Returns – Fort Lauderdale, Florida
    Fort Lauderdale, Florida - Half Moon Cay, Bahamas - At Sea - Oranjestad, Aruba - Willemstad, Curacao- At Sea - Cartagena, Colombia - Panama Canal - Gatun Lake, Panama - Panama Canal - Colon, Panama - Puerto Limon, Costa Rica - At Sea - At Sea - Fort Lauderdale, Florida
    Expedia® Extras* (Extras vary and apply to select staterooms and prices)
    • Early Booking Bonus! FREE Beverages, Specialty Dining, and more (select rates)
    • Limited Availability! Reduced Rates
    from
    $1,199* USD
    *restrictions apply


  • 10-Night Panama Canal Cruise

    FREE
    GRATUITIES*
    10-Night Panama Canal Cruise
    Princess Cruises
    Island Princess
    Depart: Sat, Nov 16, 2019
    Returns: Tue, Nov 26, 2019
    Depart – Fort Lauderdale, Florida
    • At Sea
    • Falmouth, Jamaica
    • At Sea
    • Cartagena, Colombia
    • Panama Canal
    • San Cristobal, Panama
    • Puerto Limon, Costa Rica
    • At Sea
    • Grand Cayman, Cayman Islands
    • At Sea
    Returns – Fort Lauderdale, Florida
    Fort Lauderdale, Florida - At Sea - Falmouth, Jamaica - At Sea - Cartagena, Colombia - Panama Canal - San Cristobal, Panama - Puerto Limon, Costa Rica - At Sea - Grand Cayman, Cayman Islands - At Sea - Fort Lauderdale, Florida
    Expedia® Extras* (Extras vary and apply to select staterooms and prices)
    • May Sale! FREE Gratuities, Onboard Cash Credit, Savings and more!
    from
    $849* USD
    *restrictions apply
  • 10-Night Panama Canal Cruise

    FREE
    GRATUITIES*
    10-Night Panama Canal Cruise
    Princess Cruises
    Island Princess
    Depart: Mon, Oct 7, 2019
    Returns: Thu, Oct 17, 2019
    Depart – Fort Lauderdale, Florida
    • At Sea
    • Amber Cove, Dominican Republic
    • At Sea
    • Cartagena, Colombia
    • Panama Canal
    • San Cristobal, Panama
    • Puerto Limon, Costa Rica
    • At Sea
    • Falmouth, Jamaica
    • At Sea
    Returns – Fort Lauderdale, Florida
    Fort Lauderdale, Florida - At Sea - Amber Cove, Dominican Republic - At Sea - Cartagena, Colombia - Panama Canal - San Cristobal, Panama - Puerto Limon, Costa Rica - At Sea - Falmouth, Jamaica - At Sea - Fort Lauderdale, Florida
    Expedia® Extras* (Extras vary and apply to select staterooms and prices)
    • May Sale! FREE Gratuities, Onboard Cash Credit, Savings and more!
    from
    $899* USD
    *restrictions apply
  • 16-Night Panama Canal Cruise

    16-Night Panama Canal Cruise
    Royal Caribbean International
    Vision of the Seas
    Depart: Mon, Oct 14, 2019
    Returns: Wed, Oct 30, 2019
    Depart – Miami, Florida
    • At Sea
    • At Sea
    • Cartagena, Colombia
    • Colon, Panama
    • Panama Canal
    • At Sea
    • Puntarenas, Costa Rica
    • At Sea
    • Puerto Quetzal, Guatemala
    • Huatulco, Mexico
    • At Sea
    • Puerto Vallarta, Mexico
    • Cabo San Lucas, Mexico
    • At Sea
    • At Sea
    Returns – Los Angeles, California
    Miami, Florida - At Sea - At Sea - Cartagena, Colombia - Colon, Panama - Panama Canal - At Sea - Puntarenas, Costa Rica - At Sea - Puerto Quetzal, Guatemala - Huatulco, Mexico - At Sea - Puerto Vallarta, Mexico - Cabo San Lucas, Mexico - At Sea - At Sea - Los Angeles, California
    Expedia® Extras* (Extras vary and apply to select staterooms and prices)
    • 2nd Guest 50% Off, plus 3/4 guests get 25% off – ends 6/2
    • Royal Memorial Weekend Sale! Save up to $200 Instantly - Ends 5/27
    from
    $1,060* USD
    *restrictions apply
    Gov't fees & taxes from: $360/pp.
  • 12-Night Panama Canal Cruise

    BEST
    VALUE*
    12-Night Panama Canal Cruise
    Norwegian Cruise Line
    Norwegian Pearl
    Depart: Fri, Nov 22, 2019
    Returns: Wed, Dec 4, 2019
    Depart – Miami, Florida
    • At Sea
    • At Sea
    • Cartagena, Colombia
    • Panama Canal
    • Colon, Panama
    • Puerto Limon, Costa Rica
    • At Sea
    • Roatan, Honduras
    • Harvest Caye, Belize
    • Costa Maya, Mexico
    • At Sea
    • Great Stirrup Cay, Bahamas
    Returns – Miami, Florida
    Miami, Florida - At Sea - At Sea - Cartagena, Colombia - Panama Canal - Colon, Panama - Puerto Limon, Costa Rica - At Sea - Roatan, Honduras - Harvest Caye, Belize - Costa Maya, Mexico - At Sea - Great Stirrup Cay, Bahamas - Miami, Florida
    Expedia® Extras* (Extras vary and apply to select staterooms and prices)
    • Take All Free! Open Bar, Dining, Excursions, WiFi - Ends 5/31
    • FREE Drinks, Dining, Excursion Credit & WiFi - Ends 5/31
    • FREE WiFi & Excursion Credit - Ends 5/31
    • show more 
    from
    $799* USD
    *restrictions apply
    Gov't fees & taxes from: $466/pp.
  • 12-Night Panama Canal Cruise

    BEST
    VALUE*
    12-Night Panama Canal Cruise
    Norwegian Cruise Line
    Norwegian Joy
    Depart: Sun, Oct 27, 2019
    Returns: Fri, Nov 8, 2019
    Depart – Miami, Florida
    • Great Stirrup Cay, Bahamas
    • At Sea
    • At Sea
    • Cartagena, Colombia
    • Panama Canal
    • Colon, Panama
    • Puerto Limon, Costa Rica
    • At Sea
    • Roatan, Honduras
    • Harvest Caye, Belize
    • Costa Maya, Mexico
    • At Sea
    Returns – Miami, Florida
    Miami, Florida - Great Stirrup Cay, Bahamas - At Sea - At Sea - Cartagena, Colombia - Panama Canal - Colon, Panama - Puerto Limon, Costa Rica - At Sea - Roatan, Honduras - Harvest Caye, Belize - Costa Maya, Mexico - At Sea - Miami, Florida
    Expedia® Extras* (Extras vary and apply to select staterooms and prices)
    • Take All Free! Open Bar, Dining, Excursions, WiFi - Ends 5/31
    • FREE Drinks, Dining, Excursion Credit & WiFi - Ends 5/31
    • FREE WiFi & Excursion Credit - Ends 5/31
    • show more 
    from
    $799* USD
    *restrictions apply
    Gov't fees & taxes from: $496/pp.
  • 13-Night Panama Canal Cruise

    13-Night Panama Canal Cruise
    Carnival Cruise Lines
    Carnival Miracle
    Depart: Sun, Sep 29, 2019
    Returns: Sat, Oct 12, 2019
    Depart – Tampa, Florida
    • At Sea
    • At Sea
    • Cartagena, Colombia
    • Cartagena, Colombia
    • Panama Canal
    • At Sea
    • At Sea
    • Puerto Quetzal, Guatemala
    • At Sea
    • At Sea
    • Cabo San Lucas, Mexico
    • At Sea
    Returns – Long Beach, California
    Tampa, Florida - At Sea - At Sea - Cartagena, Colombia - Cartagena, Colombia - Panama Canal - At Sea - At Sea - Puerto Quetzal, Guatemala - At Sea - At Sea - Cabo San Lucas, Mexico - At Sea - Long Beach, California
    Expedia® Extras* (Extras vary and apply to select staterooms and prices)
    • Exclusive Early Saver Sale! Reduced Deposit & $50 Credit - Ends 5/31
    • Early Saver Rates and Reduced Deposit - Ends 5/31
    • FREE Cabin Upgrade! Ends 6/2
    • show more 
    from
    $729* USD
    *restrictions apply
    Gov't fees & taxes from: $352/pp.
  • 11-Night Panama Canal Cruise

    BEST
    VALUE*
    11-Night Panama Canal Cruise
    Norwegian Cruise Line
    Norwegian Pearl
    Depart: Mon, Nov 11, 2019
    Returns: Fri, Nov 22, 2019
    Depart – Miami, Florida
    • At Sea
    • At Sea
    • Cartagena, Colombia
    • Panama Canal
    • Colon, Panama
    • Puerto Limon, Costa Rica
    • At Sea
    • Harvest Caye, Belize
    • Roatan, Honduras
    • Costa Maya, Mexico
    • At Sea
    Returns – Miami, Florida
    Miami, Florida - At Sea - At Sea - Cartagena, Colombia - Panama Canal - Colon, Panama - Puerto Limon, Costa Rica - At Sea - Harvest Caye, Belize - Roatan, Honduras - Costa Maya, Mexico - At Sea - Miami, Florida
    Expedia® Extras* (Extras vary and apply to select staterooms and prices)
    • Take All Free! Open Bar, Dining, Excursions, WiFi - Ends 5/31
    • FREE Drinks, Dining, Excursion Credit & WiFi - Ends 5/31
    • FREE WiFi & Excursion Credit - Ends 5/31
    • show more 
    from
    $929* USD
    *restrictions apply
    Gov't fees & taxes from: $420/pp.
  • 16-Night Panama Canal Cruise

    BEST
    VALUE*
    16-Night Panama Canal Cruise
    Norwegian Cruise Line
    Norwegian Bliss
    Depart: Sun, Nov 29, 2020
    Returns: Tue, Dec 15, 2020
    Depart – Miami, Florida
    • At Sea
    • At Sea
    • Willemstad, Curacao, Netherlands Antilles
    • Oranjestad, Aruba
    • At Sea
    • Panama Canal
    • At Sea
    • Caldera, Costa Rica
    • At Sea
    • Puerto Quetzal, Guatemala
    • At Sea
    • At Sea
    • Puerto Vallarta, Mexico
    • Cabo San Lucas, Mexico
    • At Sea
    Returns – Los Angeles, California
    Miami, Florida - At Sea - At Sea - Willemstad, Curacao- Oranjestad, Aruba - At Sea - Panama Canal - At Sea - Caldera, Costa Rica - At Sea - Puerto Quetzal, Guatemala - At Sea - At Sea - Puerto Vallarta, Mexico - Cabo San Lucas, Mexico - At Sea - Los Angeles, California
    Expedia® Extras* (Extras vary and apply to select staterooms and prices)
    • Take All Free! Open Bar, Dining, Excursions, WiFi - Ends 5/31
    • FREE Drinks, Dining, Excursion Credit & WiFi - Ends 5/31
    • FREE WiFi & Excursion Credit - Ends 5/31
    • show more 
    from
    $1,849* USD
    *restrictions apply
    Gov't fees & taxes from: $406/pp.
  • 14-Night Panama Canal Cruise

    BEST
    VALUE*
    14-Night Panama Canal Cruise
    Norwegian Cruise Line
    Norwegian Dawn
    Depart: Sun, Dec 1, 2019
    Returns: Sun, Dec 15, 2019
    Depart – Tampa, Florida
    • Key West, Florida
    • At Sea
    • Falmouth, Jamaica
    • At Sea
    • Santa Marta, Colombia
    • Cartagena, Colombia
    • Panama Canal
    • Colon, Panama
    • Puerto Limon, Costa Rica
    • At Sea
    • Roatan, Honduras
    • Harvest Caye, Belize
    • Costa Maya, Mexico
    • At Sea
    Returns – Tampa, Florida
    Tampa, Florida - Key West, Florida - At Sea - Falmouth, Jamaica - At Sea - Santa Marta, Colombia - Cartagena, Colombia - Panama Canal - Colon, Panama - Puerto Limon, Costa Rica - At Sea - Roatan, Honduras - Harvest Caye, Belize - Costa Maya, Mexico - At Sea - Tampa, Florida
    Expedia® Extras* (Extras vary and apply to select staterooms and prices)
    • Take All Free! Open Bar, Dining, Excursions, WiFi - Ends 5/31
    • FREE Drinks, Dining, Excursion Credit & WiFi - Ends 5/31
    • FREE WiFi & Excursion Credit - Ends 5/31
    • show more 
    from
    $1,149* USD
    *restrictions apply
    Gov't fees & taxes from: $460/pp.

Terms & Conditions

*Expedia Extras offers are per stateroom (unless otherwise stated) on select sailings, based on double occupancy, apply to new bookings only, are not combinable with any other offer, are capacity controlled and may be withdrawn without notice. Certain restrictions may apply. For full terms and conditions, click the specific Expedia Extra offer or contact your Expedia CruiseShipCenters Vacation Consultant.

For Bookings Made in Quebec: Travel Agents’ Customers Compensation Fund FICAV (0.10% or 1$ per 1000$ of tourism products).

Prices are per person (based on 2 passengers in the same stateroom), cruise only in USD dollars. Airfare, transfers, taxes, fees and port expenses are additional (unless otherwise stated). Prices vary by ship, stateroom type and sailing date. Prices and offers are subject to availability and change without notice, and are capacity controlled. Fuel supplement may apply. Expedia CruiseShipCenters is not responsible for errors that may occur due to the transfer of information from selected third parties, technical error, or human error.

Our default sort order is based on a number of relevant factors such as cruise line rating, ship rating, price per day, origin rating, destination rating, length of cruise, and booking window.

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