877-781-7447 (SHIP)

Bob Eskridge
Cruise & Vacation Consultant

Cruise Advisory
Please be aware of any coronavirus (COVID-19) cruise advisories and review updates from the World Health Organization (WHO).
Cruise Advisory
Please be aware of any coronavirus (COVID-19) cruise advisories and review updates from the World Health Organization (WHO).
  • Destinations
    South America
  • Departure Ports
    Any Port
  • Departure Date Range
    Any Date
  • Adults (25+)
    2

307 Cruises

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  • 3-Night South America Cruise

    3-Night South America Cruise
    MSC Cruises
    MSC Grandiosa
    Depart: Sat, Nov 28, 2020
    Returns: Tue, Dec 1, 2020
    Depart – Santos, Brazil
    • Buzios, Brazil
    • At Sea
    Returns – Salvador, Brazil
    Santos, Brazil - Buzios, Brazil - At Sea - Salvador, Brazil
    Expedia® Extras* (Extras vary and apply to select staterooms and prices)
    • Reduced Deposit - Only $49 per person
    from
    $379* USD
    *restrictions apply
    Gov't fees & taxes from: $42/pp.


  • 7-Night South America Cruise

    7-Night South America Cruise
    MSC Cruises
    MSC Fantasia
    Depart: Sun, Jan 31, 2021
    Returns: Sun, Feb 7, 2021
    Depart – Santos, Brazil
    • At Sea
    • Punta del Este, Uruguay
    • Buenos Aires, Argentina
    • Buenos Aires, Argentina
    • Montevideo, Uruguay
    • At Sea
    Returns – Santos, Brazil
    Santos, Brazil - At Sea - Punta del Este, Uruguay - Buenos Aires, Argentina - Buenos Aires, Argentina - Montevideo, Uruguay - At Sea - Santos, Brazil
    Expedia® Extras* (Extras vary and apply to select staterooms and prices)
    • Reduced Deposit - Only $49 per person
    from
    $679* USD
    *restrictions apply
    Gov't fees & taxes from: $98/pp.
  • 7-Night South America Cruise

    7-Night South America Cruise
    MSC Cruises
    MSC Grandiosa
    Depart: Sat, Nov 28, 2020
    Returns: Sat, Dec 5, 2020
    Depart – Santos, Brazil
    • Buzios, Brazil
    • At Sea
    • Salvador, Brazil
    • Ilheus, Brazil
    • At Sea
    • Ilha Grande, Brazil
    Returns – Santos, Brazil
    Santos, Brazil - Buzios, Brazil - At Sea - Salvador, Brazil - Ilheus, Brazil - At Sea - Ilha Grande, Brazil - Santos, Brazil
    Expedia® Extras* (Extras vary and apply to select staterooms and prices)
    • Reduced Deposit - Only $49 per person
    from
    $749* USD
    *restrictions apply
    Gov't fees & taxes from: $98/pp.
  • 7-Night South America Cruise

    7-Night South America Cruise
    MSC Cruises
    MSC Grandiosa
    Depart: Sat, Dec 5, 2020
    Returns: Sat, Dec 12, 2020
    Depart – Santos, Brazil
    • Ilha Grande, Brazil
    • At Sea
    • Salvador, Brazil
    • Ilheus, Brazil
    • At Sea
    • Buzios, Brazil
    Returns – Santos, Brazil
    Santos, Brazil - Ilha Grande, Brazil - At Sea - Salvador, Brazil - Ilheus, Brazil - At Sea - Buzios, Brazil - Santos, Brazil
    Expedia® Extras* (Extras vary and apply to select staterooms and prices)
    • Reduced Deposit - Only $49 per person
    from
    $749* USD
    *restrictions apply
    Gov't fees & taxes from: $98/pp.
  • 7-Night South America Cruise

    7-Night South America Cruise
    MSC Cruises
    MSC Fantasia
    Depart: Sun, Jan 17, 2021
    Returns: Sun, Jan 24, 2021
    Depart – Santos, Brazil
    • At Sea
    • Montevideo, Uruguay
    • Buenos Aires, Argentina
    • Buenos Aires, Argentina
    • Punta del Este, Uruguay
    • At Sea
    Returns – Santos, Brazil
    Santos, Brazil - At Sea - Montevideo, Uruguay - Buenos Aires, Argentina - Buenos Aires, Argentina - Punta del Este, Uruguay - At Sea - Santos, Brazil
    Expedia® Extras* (Extras vary and apply to select staterooms and prices)
    • Reduced Deposit - Only $49 per person
    from
    $729* USD
    *restrictions apply
    Gov't fees & taxes from: $98/pp.
  • 7-Night South America Cruise

    7-Night South America Cruise
    MSC Cruises
    MSC Grandiosa
    Depart: Sat, Dec 19, 2020
    Returns: Sat, Dec 26, 2020
    Depart – Santos, Brazil
    • Buzios, Brazil
    • At Sea
    • Salvador, Brazil
    • Ilheus, Brazil
    • At Sea
    • Ilha Grande, Brazil
    Returns – Santos, Brazil
    Santos, Brazil - Buzios, Brazil - At Sea - Salvador, Brazil - Ilheus, Brazil - At Sea - Ilha Grande, Brazil - Santos, Brazil
    from
    $839* USD
    *restrictions apply
    Gov't fees & taxes from: $98/pp.
  • 7-Night South America Cruise

    7-Night South America Cruise
    MSC Cruises
    MSC Sinfonia
    Depart: Tue, Mar 2, 2021
    Returns: Tue, Mar 9, 2021
    Depart – Buenos Aires, Argentina
    • At Sea
    • At Sea
    • IlhaBela, Brazil
    • Itajai, Brazil
    • At Sea
    • Montevideo, Uruguay
    Returns – Buenos Aires, Argentina
    Buenos Aires, Argentina - At Sea - At Sea - IlhaBela, Brazil - Itajai, Brazil - At Sea - Montevideo, Uruguay - Buenos Aires, Argentina
    Expedia® Extras* (Extras vary and apply to select staterooms and prices)
    • Reduced Deposit - Only $49 per person
    from
    $579* USD
    *restrictions apply
    Gov't fees & taxes from: $98/pp.
  • 3-Night South America Cruise

    3-Night South America Cruise
    MSC Cruises
    MSC Preziosa
    Depart: Wed, Feb 10, 2021
    Returns: Sat, Feb 13, 2021
    Depart – Rio de Janeiro, Brazil
    • Ilha Grande, Brazil
    • IlhaBela, Brazil
    Returns – Rio de Janeiro, Brazil
    Rio de Janeiro, Brazil - Ilha Grande, Brazil - IlhaBela, Brazil - Rio de Janeiro, Brazil
    Expedia® Extras* (Extras vary and apply to select staterooms and prices)
    • Reduced Deposit - Only $49 per person
    from
    $289* USD
    *restrictions apply
    Gov't fees & taxes from: $87/pp.
  • 3-Night South America Cruise

    3-Night South America Cruise
    MSC Cruises
    MSC Preziosa
    Depart: Mon, Mar 8, 2021
    Returns: Thu, Mar 11, 2021
    Depart – Santos, Brazil
    • Porto Belo, Brazil
    • Balneario Camboriu, Brazil
    Returns – Santos, Brazil
    Santos, Brazil - Porto Belo, Brazil - Balneario Camboriu, Brazil - Santos, Brazil
    Expedia® Extras* (Extras vary and apply to select staterooms and prices)
    • Reduced Deposit - Only $49 per person
    from
    $289* USD
    *restrictions apply
    Gov't fees & taxes from: $71/pp.
  • 7-Night South America Cruise

    7-Night South America Cruise
    MSC Cruises
    MSC Grandiosa
    Depart: Tue, Jan 12, 2021
    Returns: Tue, Jan 19, 2021
    Depart – Salvador, Brazil
    • Ilheus, Brazil
    • At Sea
    • Ilha Grande, Brazil
    • Santos, Brazil
    • Buzios, Brazil
    • At Sea
    Returns – Salvador, Brazil
    Salvador, Brazil - Ilheus, Brazil - At Sea - Ilha Grande, Brazil - Santos, Brazil - Buzios, Brazil - At Sea - Salvador, Brazil
    from
    $929* USD
    *restrictions apply
    Gov't fees & taxes from: $98/pp.

Terms & Conditions

*Expedia Extras offers are per stateroom (unless otherwise stated) on select sailings, based on double occupancy, apply to new bookings only, are not combinable with any other offer, are capacity controlled and may be withdrawn without notice. Certain restrictions may apply. For full terms and conditions, click the specific Expedia Extra offer or contact your Expedia CruiseShipCenters Vacation Consultant.

Prices are per person (based on 2 passengers in the same stateroom), cruise only in USD dollars. Airfare, transfers, taxes, fees and port expenses are additional (unless otherwise stated). Prices vary by ship, stateroom type and sailing date. Prices and offers are subject to availability and change without notice, and are capacity controlled. Fuel supplement may apply. Expedia CruiseShipCenters is not responsible for errors that may occur due to the transfer of information from selected third parties, technical error, or human error.

Our default sort order is based on a number of relevant factors such as cruise line rating, ship rating, price per day, origin rating, destination rating, length of cruise, and booking window.

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At Expedia CruiseShipCenters, we are navigators of spectacular vacation experiences. As part of the number one brand in travel, this is our promise to you:


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Bob Eskridge
Cruise & Vacation Consultant