1-800-745-4015

Bernadette Mercado
Cruise & Vacation Consultant

Have a Future Cruise Credit?
Our Vacation Consultants are here to help you secure an incredible deal and take the stress out of planning your next cruise. Find out more
Have a Future Cruise Credit?
Our Vacation Consultants are here to help you secure an incredible deal and take the stress out of planning your next cruise. Find out more
  • Destinations
    South America
  • Departure Ports
    Any Port
  • Departure Date Range
    Any Date
  • Adults (25+)
    2

314 Cruises

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  • 7-Night South America Cruise

    7-Night South America Cruise
    MSC Cruises
    MSC Sinfonia
    Depart: Sat, Jan 16, 2021
    Returns: Sat, Jan 23, 2021
    Depart – Itajai, Brazil
    • At Sea
    • Montevideo, Uruguay
    • Buenos Aires, Argentina
    • At Sea
    • At Sea
    • IlhaBela, Brazil
    Returns – Itajai, Brazil
    Itajai, Brazil - At Sea - Montevideo, Uruguay - Buenos Aires, Argentina - At Sea - At Sea - IlhaBela, Brazil - Itajai, Brazil
    from
    $669* USD
    *restrictions apply
    Gov't fees & taxes from: $165/pp.


  • 3-Night South America Cruise

    3-Night South America Cruise
    MSC Cruises
    MSC Preziosa
    Depart: Tue, Mar 2, 2021
    Returns: Fri, Mar 5, 2021
    Depart – Santos, Brazil
    • Porto Belo, Brazil
    • Balneario Camboriu, Brazil
    Returns – Santos, Brazil
    Santos, Brazil - Porto Belo, Brazil - Balneario Camboriu, Brazil - Santos, Brazil
    Expedia® Extras* (Extras vary and apply to select staterooms and prices)
    • Reduced Deposit - Only $49 per person
    from
    $289* USD
    *restrictions apply
    Gov't fees & taxes from: $59/pp.
  • 4-Night South America Cruise

    4-Night South America Cruise
    MSC Cruises
    MSC Preziosa
    Depart: Tue, Dec 1, 2020
    Returns: Sat, Dec 5, 2020
    Depart – Santos, Brazil
    • Rio de Janeiro, Brazil
    • At Sea
    • IlhaBela, Brazil
    Returns – Rio de Janeiro, Brazil
    Santos, Brazil - Rio de Janeiro, Brazil - At Sea - IlhaBela, Brazil - Rio de Janeiro, Brazil
    Expedia® Extras* (Extras vary and apply to select staterooms and prices)
    • Reduced Deposit - Only $49 per person
    from
    $299* USD
    *restrictions apply
    Gov't fees & taxes from: $56/pp.
  • 14-Night South America Cruise

    14-Night South America Cruise
    Norwegian Cruise Line
    Norwegian Star
    Depart: Sat, Dec 19, 2020
    Returns: Sat, Jan 2, 2021
    Depart – Buenos Aires, Argentina
    • Montevideo, Uruguay
    • At Sea
    • Puerto Madryn, Argentina
    • At Sea
    • Port Stanley, Falkland Islands (Malvinas)
    • Cape Horn, Chile
    • Ushuaia, Argentina
    • Punta Arenas, Chile
    • At Sea
    • At Sea
    • Puerto Chacabuco, Chile
    • Puerto Montt, Chile
    • At Sea
    Returns – San Antonio, Chile
    Buenos Aires, Argentina - Montevideo, Uruguay - At Sea - Puerto Madryn, Argentina - At Sea - Port Stanley, Falkland Islands (Malvinas) - Cape Horn, Chile - Ushuaia, Argentina - Punta Arenas, Chile - At Sea - At Sea - Puerto Chacabuco, Chile - Puerto Montt, Chile - At Sea - San Antonio, Chile
    Expedia® Extras* (Extras vary and apply to select staterooms and prices)
    • FREE Dining, Excursion Credit & WiFi
    • FREE Drinks, Dining, Excursion Credit & WiFi
    • FREE Drinks, Excursion Credit & WiFi
    • show more 
    from
    $1,079* USD
    *restrictions apply
    Gov't fees & taxes from: $384/pp.
  • 14-Night South America Cruise

    up to
    $1000
    CREDIT*
    14-Night South America Cruise
    Norwegian Cruise Line
    Norwegian Star
    Depart: Sat, Feb 27, 2021
    Returns: Sat, Mar 13, 2021
    Depart – San Antonio, Chile
    • At Sea
    • Puerto Montt, Chile
    • At Sea
    • At Sea
    • Punta Arenas, Chile
    • Ushuaia, Argentina
    • Cape Horn, Chile
    • Port Stanley, Falkland Islands (Malvinas)
    • At Sea
    • Puerto Madryn, Argentina
    • At Sea
    • Punta del Este, Uruguay
    • Montevideo, Uruguay
    Returns – Buenos Aires, Argentina
    San Antonio, Chile - At Sea - Puerto Montt, Chile - At Sea - At Sea - Punta Arenas, Chile - Ushuaia, Argentina - Cape Horn, Chile - Port Stanley, Falkland Islands (Malvinas) - At Sea - Puerto Madryn, Argentina - At Sea - Punta del Este, Uruguay - Montevideo, Uruguay - Buenos Aires, Argentina
    Expedia® Extras* (Extras vary and apply to select staterooms and prices)
    • Dash Sale! Up to $1000 Onboard Cash Credit - Ends 5/31
    • FREE Dining, Excursion Credit & WiFi
    • FREE Drinks, Dining, Excursion Credit & WiFi
    • show more 
    from
    $1,029* USD
    *restrictions apply
    Gov't fees & taxes from: $424/pp.
  • 7-Night South America Cruise

    up to
    $1000
    CREDIT*
    7-Night South America Cruise
    Norwegian Cruise Line
    Norwegian Star
    Depart: Sun, Mar 12, 2023
    Returns: Sun, Mar 19, 2023
    Depart – Buenos Aires, Argentina
    • Punta del Este, Uruguay
    • At Sea
    • Santos, Brazil
    • Ilha Grande, Brazil
    • Buzios, Brazil
    • Rio de Janeiro, Brazil
    Returns – Rio de Janeiro, Brazil
    Buenos Aires, Argentina - Punta del Este, Uruguay - At Sea - Santos, Brazil - Ilha Grande, Brazil - Buzios, Brazil - Rio de Janeiro, Brazil - Rio de Janeiro, Brazil
    Expedia® Extras* (Extras vary and apply to select staterooms and prices)
    • Dash Sale! Up to $1000 Onboard Cash Credit - Ends 5/31
    • FREE Dining, Excursion Credit & WiFi
    • FREE Drinks, Dining, Excursion Credit & WiFi
    • show more 
    from
    $699* USD
    *restrictions apply
    Gov't fees & taxes from: $308/pp.
  • 14-Night South America Cruise

    BEST
    VALUE*
    14-Night South America Cruise
    Celebrity Cruises
    Celebrity Silhouette
    Depart: Sun, Dec 6, 2020
    Returns: Sun, Dec 20, 2020
    Depart – Buenos Aires, Argentina
    • Buenos Aires, Argentina
    • Montevideo, Uruguay
    • Punta del Este, Uruguay
    • At Sea
    • Puerto Madryn, Argentina
    • At Sea
    • Cape Horn, Chile
    • Ushuaia, Argentina
    • Punta Arenas, Chile
    • Strait of Magellan, Chile
    • Chilean Fjords, Chile
    • Puerto Montt, Chile
    • At Sea
    Returns – San Antonio, Chile
    Buenos Aires, Argentina - Buenos Aires, Argentina - Montevideo, Uruguay - Punta del Este, Uruguay - At Sea - Puerto Madryn, Argentina - At Sea - Cape Horn, Chile - Ushuaia, Argentina - Punta Arenas, Chile - Strait of Magellan, Chile - Chilean Fjords, Chile - Puerto Montt, Chile - At Sea - San Antonio, Chile
    Expedia® Extras* (Extras vary and apply to select staterooms and prices)
    • Up to $1000 Savings on refundable fares
    • Sail Plus! Beverage Package & WiFi
    • Sail Plus! Beverage Package & Tips
    • show more 
    from
    $1,624* USD
    *restrictions apply
    Gov't fees & taxes from: $338/pp.
  • 7-Night South America Cruise

    up to
    $1000
    CREDIT*
    7-Night South America Cruise
    Norwegian Cruise Line
    Norwegian Star
    Depart: Sun, Dec 11, 2022
    Returns: Sun, Dec 18, 2022
    Depart – Rio de Janeiro, Brazil
    • Rio de Janeiro, Brazil
    • Buzios, Brazil
    • Ilha Grande, Brazil
    • Santos, Brazil
    • At Sea
    • Punta del Este, Uruguay
    Returns – Buenos Aires, Argentina
    Rio de Janeiro, Brazil - Rio de Janeiro, Brazil - Buzios, Brazil - Ilha Grande, Brazil - Santos, Brazil - At Sea - Punta del Este, Uruguay - Buenos Aires, Argentina
    Expedia® Extras* (Extras vary and apply to select staterooms and prices)
    • Dash Sale! Up to $1000 Onboard Cash Credit - Ends 5/31
    • FREE Dining, Excursion Credit & WiFi
    • FREE Drinks, Dining, Excursion Credit & WiFi
    • show more 
    from
    $599* USD
    *restrictions apply
    Gov't fees & taxes from: $256/pp.
  • 7-Night South America Cruise

    7-Night South America Cruise
    MSC Cruises
    MSC Sinfonia
    Depart: Sat, Mar 6, 2021
    Returns: Sat, Mar 13, 2021
    Depart – Itajai, Brazil
    • At Sea
    • Montevideo, Uruguay
    • Buenos Aires, Argentina
    • At Sea
    • At Sea
    • IlhaBela, Brazil
    Returns – Itajai, Brazil
    Itajai, Brazil - At Sea - Montevideo, Uruguay - Buenos Aires, Argentina - At Sea - At Sea - IlhaBela, Brazil - Itajai, Brazil
    Expedia® Extras* (Extras vary and apply to select staterooms and prices)
    • Reduced Deposit - Only $49 per person
    from
    $579* USD
    *restrictions apply
    Gov't fees & taxes from: $165/pp.
  • 14-Night South America Cruise

    BEST
    VALUE*
    14-Night South America Cruise
    Celebrity Cruises
    Celebrity Silhouette
    Depart: Sun, Dec 20, 2020
    Returns: Sun, Jan 3, 2021
    Depart – San Antonio, Chile
    • At Sea
    • Puerto Montt, Chile
    • Chilean Fjords, Chile
    • Strait of Magellan, Chile
    • Punta Arenas, Chile
    • Ushuaia, Argentina
    • Cape Horn, Chile
    • At Sea
    • Puerto Madryn, Argentina
    • At Sea
    • Punta del Este, Uruguay
    • Montevideo, Uruguay
    • Buenos Aires, Argentina
    Returns – Buenos Aires, Argentina
    San Antonio, Chile - At Sea - Puerto Montt, Chile - Chilean Fjords, Chile - Strait of Magellan, Chile - Punta Arenas, Chile - Ushuaia, Argentina - Cape Horn, Chile - At Sea - Puerto Madryn, Argentina - At Sea - Punta del Este, Uruguay - Montevideo, Uruguay - Buenos Aires, Argentina - Buenos Aires, Argentina
    Expedia® Extras* (Extras vary and apply to select staterooms and prices)
    • Up to $1000 Savings on refundable fares
    • Sail Plus! Beverage Package & WiFi
    • Sail Plus! Beverage Package & Tips
    • show more 
    from
    $1,829* USD
    *restrictions apply
    Gov't fees & taxes from: $315/pp.

Terms & Conditions

*Expedia Extras offers are per stateroom (unless otherwise stated) on select sailings, based on double occupancy, apply to new bookings only, are not combinable with any other offer, are capacity controlled and may be withdrawn without notice. Certain restrictions may apply. For full terms and conditions, click the specific Expedia Extra offer or contact your Expedia CruiseShipCenters Vacation Consultant.

Prices are per person (based on 2 passengers in the same stateroom), cruise only in USD dollars. Airfare, transfers, taxes, fees and port expenses are additional (unless otherwise stated). Prices vary by ship, stateroom type and sailing date. Prices and offers are subject to availability and change without notice, and are capacity controlled. Fuel supplement may apply. Expedia CruiseShipCenters is not responsible for errors that may occur due to the transfer of information from selected third parties, technical error, or human error.

Our default sort order is based on a number of relevant factors such as cruise line rating, ship rating, price per day, origin rating, destination rating, length of cruise, and booking window.

Our Promise


At Expedia CruiseShipCenters, we are navigators of spectacular vacation experiences. As part of the number one brand in travel, this is our promise to you:


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  • Advice you can trust.

  • The best choice in prices.

  • Expedia Extras.

  • More than cruises.

  • Always there.


Bernadette Mercado
Cruise & Vacation Consultant