703-822-4277

Visit us at 20808 Edds Lane
Sterling, VA 20165

Have a Future Cruise Credit?
Our Vacation Consultants are here to help you secure an incredible deal and take the stress out of planning your next cruise. Find out more
Have a Future Cruise Credit?
Our Vacation Consultants are here to help you secure an incredible deal and take the stress out of planning your next cruise. Find out more
  • Destinations
    South America
  • Departure Ports
    Any Port
  • Departure Date Range
    Any Date
  • Adults (25+)
    2

314 Cruises

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  • 7-Night South America Cruise

    7-Night South America Cruise
    MSC Cruises
    MSC Fantasia
    Depart: Sun, Jan 24, 2021
    Returns: Sun, Jan 31, 2021
    Depart – Santos, Brazil
    • At Sea
    • Montevideo, Uruguay
    • Buenos Aires, Argentina
    • Buenos Aires, Argentina
    • Punta del Este, Uruguay
    • At Sea
    Returns – Santos, Brazil
    Santos, Brazil - At Sea - Montevideo, Uruguay - Buenos Aires, Argentina - Buenos Aires, Argentina - Punta del Este, Uruguay - At Sea - Santos, Brazil
    Expedia® Extras* (Extras vary and apply to select staterooms and prices)
    • Reduced Deposit - Only $49 per person
    from
    $729* USD
    *restrictions apply
    Gov't fees & taxes from: $98/pp.


  • 4-Night South America Cruise

    4-Night South America Cruise
    MSC Cruises
    MSC Grandiosa
    Depart: Tue, Feb 9, 2021
    Returns: Sat, Feb 13, 2021
    Depart – Salvador, Brazil
    • Ilheus, Brazil
    • At Sea
    • Buzios, Brazil
    Returns – Santos, Brazil
    Salvador, Brazil - Ilheus, Brazil - At Sea - Buzios, Brazil - Santos, Brazil
    Expedia® Extras* (Extras vary and apply to select staterooms and prices)
    • Reduced Deposit - Only $49 per person
    from
    $509* USD
    *restrictions apply
    Gov't fees & taxes from: $56/pp.
  • 7-Night South America Cruise

    7-Night South America Cruise
    MSC Cruises
    MSC Fantasia
    Depart: Sun, Dec 20, 2020
    Returns: Sun, Dec 27, 2020
    Depart – Santos, Brazil
    • At Sea
    • Montevideo, Uruguay
    • Buenos Aires, Argentina
    • Buenos Aires, Argentina
    • Punta del Este, Uruguay
    • At Sea
    Returns – Santos, Brazil
    Santos, Brazil - At Sea - Montevideo, Uruguay - Buenos Aires, Argentina - Buenos Aires, Argentina - Punta del Este, Uruguay - At Sea - Santos, Brazil
    from
    $739* USD
    *restrictions apply
    Gov't fees & taxes from: $98/pp.
  • 7-Night South America Cruise

    7-Night South America Cruise
    MSC Cruises
    MSC Grandiosa
    Depart: Tue, Dec 8, 2020
    Returns: Tue, Dec 15, 2020
    Depart – Salvador, Brazil
    • Ilheus, Brazil
    • At Sea
    • Buzios, Brazil
    • Santos, Brazil
    • Buzios, Brazil
    • At Sea
    Returns – Salvador, Brazil
    Salvador, Brazil - Ilheus, Brazil - At Sea - Buzios, Brazil - Santos, Brazil - Buzios, Brazil - At Sea - Salvador, Brazil
    from
    $749* USD
    *restrictions apply
    Gov't fees & taxes from: $98/pp.
  • 3-Night South America Cruise

    3-Night South America Cruise
    MSC Cruises
    MSC Preziosa
    Depart: Sun, Nov 22, 2020
    Returns: Wed, Nov 25, 2020
    Depart – Santos, Brazil
    • Buzios, Brazil
    • Ilha Grande, Brazil
    Returns – Santos, Brazil
    Santos, Brazil - Buzios, Brazil - Ilha Grande, Brazil - Santos, Brazil
    Expedia® Extras* (Extras vary and apply to select staterooms and prices)
    • Reduced Deposit - Only $49 per person
    from
    $279* USD
    *restrictions apply
    Gov't fees & taxes from: $71/pp.
  • 7-Night South America Cruise

    7-Night South America Cruise
    MSC Cruises
    MSC Fantasia
    Depart: Sun, Jan 3, 2021
    Returns: Sun, Jan 10, 2021
    Depart – Santos, Brazil
    • At Sea
    • Montevideo, Uruguay
    • Buenos Aires, Argentina
    • Buenos Aires, Argentina
    • Punta del Este, Uruguay
    • At Sea
    Returns – Santos, Brazil
    Santos, Brazil - At Sea - Montevideo, Uruguay - Buenos Aires, Argentina - Buenos Aires, Argentina - Punta del Este, Uruguay - At Sea - Santos, Brazil
    from
    $729* USD
    *restrictions apply
    Gov't fees & taxes from: $98/pp.
  • 3-Night South America Cruise

    3-Night South America Cruise
    MSC Cruises
    MSC Preziosa
    Depart: Tue, Mar 2, 2021
    Returns: Fri, Mar 5, 2021
    Depart – Santos, Brazil
    • Porto Belo, Brazil
    • Balneario Camboriu, Brazil
    Returns – Santos, Brazil
    Santos, Brazil - Porto Belo, Brazil - Balneario Camboriu, Brazil - Santos, Brazil
    Expedia® Extras* (Extras vary and apply to select staterooms and prices)
    • Reduced Deposit - Only $49 per person
    from
    $289* USD
    *restrictions apply
    Gov't fees & taxes from: $59/pp.
  • 3-Night South America Cruise

    3-Night South America Cruise
    MSC Cruises
    MSC Preziosa
    Depart: Fri, Feb 26, 2021
    Returns: Mon, Mar 1, 2021
    Depart – Rio de Janeiro, Brazil
    • IlhaBela, Brazil
    • Ilha Grande, Brazil
    Returns – Rio de Janeiro, Brazil
    Rio de Janeiro, Brazil - IlhaBela, Brazil - Ilha Grande, Brazil - Rio de Janeiro, Brazil
    Expedia® Extras* (Extras vary and apply to select staterooms and prices)
    • Reduced Deposit - Only $49 per person
    from
    $329* USD
    *restrictions apply
    Gov't fees & taxes from: $42/pp.
  • 7-Night South America Cruise

    7-Night South America Cruise
    MSC Cruises
    MSC Grandiosa
    Depart: Sat, Jan 16, 2021
    Returns: Sat, Jan 23, 2021
    Depart – Santos, Brazil
    • Buzios, Brazil
    • At Sea
    • Salvador, Brazil
    • Ilheus, Brazil
    • At Sea
    • Ilha Grande, Brazil
    Returns – Santos, Brazil
    Santos, Brazil - Buzios, Brazil - At Sea - Salvador, Brazil - Ilheus, Brazil - At Sea - Ilha Grande, Brazil - Santos, Brazil
    Expedia® Extras* (Extras vary and apply to select staterooms and prices)
    • Reduced Deposit - Only $49 per person
    from
    $839* USD
    *restrictions apply
    Gov't fees & taxes from: $98/pp.
  • 3-Night South America Cruise

    3-Night South America Cruise
    MSC Cruises
    MSC Preziosa
    Depart: Fri, Mar 5, 2021
    Returns: Mon, Mar 8, 2021
    Depart – Santos, Brazil
    • Buzios, Brazil
    • Ilha Grande, Brazil
    Returns – Santos, Brazil
    Santos, Brazil - Buzios, Brazil - Ilha Grande, Brazil - Santos, Brazil
    from
    $329* USD
    *restrictions apply
    Gov't fees & taxes from: $42/pp.

Terms & Conditions

*Expedia Extras offers are per stateroom (unless otherwise stated) on select sailings, based on double occupancy, apply to new bookings only, are not combinable with any other offer, are capacity controlled and may be withdrawn without notice. Certain restrictions may apply. For full terms and conditions, click the specific Expedia Extra offer or contact your Expedia CruiseShipCenters Vacation Consultant.

Prices are per person (based on 2 passengers in the same stateroom), cruise only in USD dollars. Airfare, transfers, taxes, fees and port expenses are additional (unless otherwise stated). Prices vary by ship, stateroom type and sailing date. Prices and offers are subject to availability and change without notice, and are capacity controlled. Fuel supplement may apply. Expedia CruiseShipCenters is not responsible for errors that may occur due to the transfer of information from selected third parties, technical error, or human error.

Our default sort order is based on a number of relevant factors such as cruise line rating, ship rating, price per day, origin rating, destination rating, length of cruise, and booking window.

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At Expedia CruiseShipCenters, we are navigators of spectacular vacation experiences. As part of the number one brand in travel, this is our promise to you:


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